Thursday, 24 October 2013

Something Wicked This Way Comes

In the February of 1692, two girls from Salem Village in the young American colonies began to suffer from strange fits that left them screaming, uttering strange sounds, contorting into strange positions, and with violent outbursts. A minister from a nearby town described their illness as “beyond the power of Epileptic Fits or natural disease to effect” and – assuming that only the supernatural could cause this illness - the Salem Village soon began the famous Salem Witch Trials.

Swept up by hysteria, everyone accused their neighbors, friends, and family of witchcraft. The town executed twenty people, nineteen by hanging and one by pressing to death when he failed to plead guilty. Five more of the accused died in prison.  The final trial took place in May 1693 and, with the defendants found not guilty, the case officially ended – at least judicially. The trials never died in the mind of the public, however, and for the decades and centuries that followed it obsessed the public with its plethora of unanswered questions.

The Crucible, by Arthur Miller, is based on the witch trials.

One of the main questions: what caused those girls to act so strangely and spark the craze of paranoia that led to so many deaths? Many theories have been put forward throughout the centuries, mostly based on the assumption that the girls faked their illness either to fuel family rivalries or as a cruel prank.

In 1976, Linnda R. Carporael proposed a new hypothesis: that the girls were suffering from poisoning by ergot-tainted rye. Their symptoms cited in the trials – convulsion, hallucination, crawling sensations in the skin, tingling in the fingers, headaches, vomiting, diarrhea, mania, psychosis, and delirium – match that of ergotism. Moreover, there was an abundance of rye in the area and, during those years, the right weather conditions for ergot to flourish. Although this theory has been subject to some academic debate, it is still one of the most widely accepted reasons behind the seventeenth century hysteria. 

Ergot is a group of fungus whose consumption causes a number of severe pathological syndromes in humans or other animals. As early as 1095, a special hospital was founded to treat the symptoms of ergotism. The condition gained the nickname “St. Anthony’s Fire” for the order of monks who founded the hospital and the burning sensation ergot poisoning causes in the limbs of the contaminated.
The effects of ergot have also been used deliberately in drugs. As Paul L. Schiff Jr. explains:
In 1582 a preparation of ergot that was employed in small doses by midwives to produce strong uterine contractions was described by Adam Lonicer in his Kreuterbuch. The use of ergot as an oxytocic in childbirth became very popular in France, Germany, and the United States. The first use of the drug in official medicine was described by the American physician John Stearns in 1808, when he reported on the uterine contractile actions of a preparation of ergot obtained from blackened granary rye as a remedy for “quickening childbirth.” However, shortly thereafter the number of stillborn neonates rose to a point that the Medical Society of New York initiated an investigation. As a result of this enquiry, it was recommended in 1824 that ergot only be used in the control of postpartum hemorrhage. Ergot was introduced into the first edition of the United States Pharmacopeia in 1820 and into the London Pharmacopeia in 1836.
In modern pharmaceuticals, ergot is used in medicines in the form of ergotamine. One example is Cafergot, a Novartis drug which is used to treat migraine headaches. Although cases are rare, the Novartis Consumer Information cites a risk of developing ergotism associated with the drug. Cafergot was discontinued in the UK in 2012. Ergoline alkaloids, originally isolated from ergot fungus, is also used in pharmaceuticals for the treatment of Parkinson’s disease, albeit usually in synthetic derivatives.
It is incredible to consider that we are now able to harness this poison - which has tortured humanity for millennia – for good. Yet the risk of poisoning still remains high, with several outbreaks of ergotism in the twentieth century. The risk of witchcraft accusations may be lower in this day and age, but with Halloween approaching… perhaps it’s best if you watch what you eat.
Paul L. Schiff, Jr. "Ergot and Its Alkaloids" in the American Journal of Pharmaceutical Education, October 15 2006.
“Ergot” from Wikipedia.
“Ergotism” from Wikipedia.
“Ergotamine” from Wikipedia.
“Salem Witch Trials” from Wikipedia.
"Cafergot” from
“Cafergot: Consumer Information” from the Novartis Canadian Website

No comments: